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Sepsis, one of the leading causes of death worldwide, occurs when a local microbial infection spreads into blood circulation triggering a vigorous inflammatory response. This response can result in multiple organ failure which is usually fatal.
Thus, early diagnosis is the only way to increase the survival rate. The aim of this project is the development of a multi-analyte optical label-free biosensor based on White Light Reflectance Spectroscopy (WLRS) for sepsis diagnosis through the rapid and accurate determination of a panel of three analytes related to sepsis in whole blood samples. The targeted analytes are C-reactive protein, procalcitonin and inteleukine-6. The simultaneous determination of these markers is essential to sepsis diagnosis. In combination with the overall clinical picture of the patient could help to manage successfully the treatment. The sensor will be accompanied by a compact small size instrument with automated data processing appropriate for Point-of-Care testing.
